FORTAF: Fortifying Africa’s Future - Fortifier L’avenir de L’Afrique

 

Key facts on vitamins and minerals

Iron Deficiency and Anaemia:

Prevalence Risk factors Consequences
» Most common nutritional disorder worldwide.
» 244 million people (46%) in Africa suffer from anaemia.
» Food intake: Low intakes of meat/fish/poultry, high intakes of phytates (legumes, cereals); Low intakes of Vitamin C, Allergy to cow's milk
» Physiology: Preterm delivery or Low birth weight; Pregnancy and adolescence - periods of high iron requirement; Heavy menstrual losses
» Infections: Parasite infections (i.e. hookworm, schistosomiasis, ascaris) - which cause heavy blood losses; Malaria (causes anaemia, not iron deficiency)
» Anaemia
» Increased risk of maternal mortality and child mortality (severe anaemia)
» Reduced cognitive performance resulting in lower school performance, and 2.5% drop in future productivity
» Lower work performance and endurance (5-17%)
» Impaired iodine and Vitamin A metabolism

Vitamin A Deficiency:

Prevalence Risk factors Consequences
» 53 million (49%) preschool children in Africa affected
» Low intakes of dairy products, eggs, and ?-carotene from fruits and vegetables
» Parasite infections (ascaris)
» Increased risk of mortality in children and pregnant women. Risk of death from childhood diseases increases by as much as 23-40%.
» Increases the risk of severe illness and recovery time from common infections such as measles and malaria
» Increase clinic attendance and health care costs
» Leading global cause of preventable childhood blindness
» Night blindness, xerophthalmia

Iodine Deficiency Disorders:

Prevalence Risk factors Consequences
» 260 million people (43%) in Africa have insufficient iodine intakes
» Residence in areas with low levels of iodine in soil and water
» Living in high altitude regions, river plains, far from sea
» Consumption of non-detoxified cassava
» Consumption of non- iodised salt
» Birth defects
» Increased risk of stillbirth and infant mortality
» Cognitive and neurological impairment, including cretinism
» Impaired cognitive functioning
» Hypothyroidism
» Goitre

Zinc Deficiency:

Prevalence Risk factors Consequences
» Moderate to high prevalence in Africa
» Low intakes of animal products
» High phytate intakes (cereals and legumes)
» Malabsorption and infection with intestinal parasites
» Diarrhoea, especially persistent
» Genetic disorders
» Non-specific if marginal deficiency
» Poor pregnancy outcomes
» Impaired growth (stunting)
» Lowered resistance to infections, particularly diarrhea
» Severe deficiency results in dermatitis, retarded growth, diarrhea, mental disturbance, delayed sexual maturation, recurrent infections

B-Vitamin Deficiency Disorders:

Prevalence Risk factors Consequences
Folate (Vitamin B9)    
» Prevalence unknown
» Low intakes of fruits and vegetables, legumes and dairy products
» Malabsorption and intestinal parasites
» Genetic disorders of folic acid metabolism
» Megaloblastic anaemia
» Risk factor for neural tube and other birth defects
» Elevated plasma homocysteine
» Heart disease and stroke
» Impaired cognitive function
» Depression
Vitamin B12 (Cobalamin)    
» Prevalence unknown
» Low intakes of animal products
» Malabsorption from food due to gastric atrophy or bacterial overgrowth
» Genetic disorders of Vitamin B12 metabolism
» Megaloblastic anaemia
» Severe deficiency can cause developmental delays, poor growth in infants and children, neurological dysfunction
» Risk factor for neural tube defects, elevated plasma homocysteine and impaired cognitive function
Vitamin B1 (thiamine)    
» Insufficient data on prevalence
» Regularly reported in famine situations and among displaced populations
» High consumption of refined rice and cereals
» Low intakes of animal and dairy products, and legumes
» Breastfeeding from deficient mothers
» Chronic alcoholism
» Genetic disorder of thiamine metabolism
» Beriberi (severe deficiency) presents in two forms:
  Cardiac form, with risk of heart failure (predominant in neonates)
  Neurological, with chronic peripheral neuropathy (loss of sensation and reflexes)
» Wernicke-Korsakov syndrome (usually in alcoholics) with confusion, lack of coordination and paralysis
Vitamin B2 (Riboflavin)    
» Insufficient data on prevalence, likely to be very common in African countries
» Low intakes of animal and dairy products
» Chronic alcoholism
» Non-specific, can include
Fatigue
Eye changes
Dermatitis
Brain dysfunction
Impaired iron absorption and utilization
Vitamin B3 (Niacin)    
» Insufficient data on marginal deficiency
» Severe deficiency in form of pellagra occur in parts of Africa, among displaced people and in famine situations
» Low intakes of animal and dairy products
» High consumption of refined cereals
» Maize-based diets (not lime treated)
» Severe deficiency results in pellagra
» Dermatitis
» Digestive mucosa disorders, including diarrhea and vomiting
» Neurological symptoms, depression, memory loss
Vitamin B6    
» Insufficient data on prevalence, likely to be widespread in Africa
» Typically associated with deficiencies in other B-vitamins
» Low intakes of animal products
» High consumption of refined cereals
» Chronic alcoholism
»
»
» Non-specific symptoms, may include
Neurological disorders, convulsions
Dermatitis
Anaemia
Risk factor for elevated plasma homocysteine

Vitamin C (Ascorbic Acid) Deficiency:

Prevalence Risk factors Consequences
» Insufficient data on moderate deficiencies
» Severe deficiency (scurvy) occurs in famine situations and among displaced people dependent on food aid for a long time
» Low intake of fresh vitamin C-rich fruits and vegetables
» Prolonged cooking of vegetables
» Severe deficiency results in scurvy with bleedings gums, joint and muscle pain, peripheral oedema
» Anaemia

Vitamin D deficiency:

Prevalence Risk factors Consequences
» Insufficient data on prevalence, likely to be prevalent in some parts of Africa
» More prevalent in at northerly or southerly latitudes, where daylight hours are limited during winter months
» Low exposure to ultra-violet radiation
» Wearing excess clothing
» Having darkly pigmented skin
» Rickets in Children and Osteomalacia in adults
» Linked to range of diseases and health problems including cancer, multiple sclerosis, diabetes

Calcium Deficiency:

Prevalence Risk factors Consequences
» Insufficient data, low intakes very common
» Low intakes of dairy products
» Decreased bone mineralization
» Increased risk of osteoporosis in adults
» Increased risk of rickets in children

For more information on vitamin and mineral deficiencies, see Allen, L, De Benoist, B, Dary, O, and Hurrell, R (eds). Guidelines on food fortification with micronutrients. 2006. WHO and FAO. Geneva.

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